M. J. Nutt, S. G. Stewart, Strengthening Molecular Glues: Design Strategies for Improving Thalidomide Analogues as Cereblon Effectors and Anti-Cancer Agents, 2024, Drug Discovery Today, https://doi.org/10.1016/j.drudis.2024.104010
M. J. Nutt, J. W. Annear, K. D. Jones, G. R. Flematti, S. A. Moggach, S. G. Stewart Dirhodium-Catalyzed Transannulation of N-Sulfonyl-1,2,3-triazoles to 2,3-Dehydropiperazines, The Journal of Organic Chemistry, Articles ASAP, July 31, 2023 DOI: 10.1021/acs.joc.3c01259.
M. J. Nutt, N. Woolf , S. G. Stewart Overview of the synthetic approaches to lysergic acid as a precursor to the psychedelic LSD. Australian Journal of Chemistry 2023, 76, 279–287.
L. Joyce; S. A. Moggach; C. J. T. Hyland; S. G. Pyne; S. G. Stewart. Nickel Phosphite-Catalyzed Tetradehydro-Diels–Alder Reactions of (E)-3-ene-1,8-diynes, J. Org. Chem. 2023,
N. Gunawan, M. J. Nutt, A. C. Bissember, J. Smith , S. G. Stewart; N-Tosyl-1,2,3-triazoles as Scaffolds for Morpholines: The Total Synthesis of (–)-Chelonin A, Synlett 2023, 34, A–E.
M. J. Nutt, Y. Sing-Yee, A. Buyan, N. Andrewartha, B. Corry, G. CT Yeoh, S. G. Stewart, In pursuit of a selective hepatocellular carcinoma therapeutic agent: Novel thalidomide derivatives with antiproliferative, antimigratory and STAT3 inhibitory properties, Eur J Med Chem, 2021, 217, 113353.
Y Teng, S. G. Stewart, Y-W Hai, X. Li, M. G. Banwell, P. Lan, Sucrose fatty acid esters: synthesis, emulsifying capacities, biological activities and structure-property profiles, Crit Rev Food Sci Nutr, 2021, 19, 3297-3317.
S G Stewart, J A Smith, R Condie, Three or Four Heteroatoms Including At Least One Boron, Comprehensive Heterocyclic Chemistry III, 2021.V 6, pg 615-654, Elsevier.
S. G. Stewart, G. J Harfoot, K. J McRae, Y. Teng, Li-Juan Yu, Bo. Chen, R. Cammi, M. L Coote, M. G. Banwell, A. C Willis, High-Pressure-Promoted and Facially Selective Diels–Alder Reactions of Enzymatically Derived cis-1,2-Dihydrocatechols and Their Acetonide Derivatives, J. Org. Chem. 2020, 85, 20, 13080-13095.
K. D. Jones, M. J. Nutt, E. Comninos, A. N. Sobolev, S. A. Moggach, T. Miura, M. Murakami, S. G. Stewart, A One-Pot Reaction of α-Imino Rhodium Carbenoids and Halohydrins: Access to 2,6-Substituted Dihydro-2H-1,4-oxazines, Org Lett, 2020, 22, 3490-3494.
J. Duczynski, A. N. Sobolev, S. A. Moggach, R. Dorta, S. G. Stewart, The Synthesis and Catalytic Activity of New Mixed NHC-Phosphite Nickel(0) Complexes, Organometallics 2020, 39, 105-115.
T. Miura, T. Nakamuro, Y. Nagata, D. Moriyama, S. G. Stewart, M. Murakami, Asymmetric Synthesis and Stereochemical Assignment of 12C/13C Isotopomers, J. Am. Chem. Soc. 2019, 141, 13341-13345.
J. Hu, F. Sarrami, H. Li, G. Zhang, K. A Stubbs, E. Lacey, S. G Stewart, A. Karton, A. M Piggott, Yit-Heng Chooi, Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system. Chemical Science 2019, 10, 1457-1465.
K. D. Jones, D. J. Power, D. Bierer, K M. Gericke, S G. Stewart. Nickel Phosphite/Phosphine-Catalyzed C–S Cross-Coupling of Aryl Chlorides and Thiols, Org. Lett., 2018, 20, 208–211.
T. Miura, J. Nakahashi, W. Zhou, Y. Shiratori, S. G. Stewart, M. Murakami, Enantioselective Synthesis of anti-1,2-Oxaborinan-3-enes from Aldehydes and 1,1-Di(boryl)alk-3-enes Using Ruthenium and Chiral Phosphoric Acid Catalysts, J. Am. Chem. Soc., 2017, 139, 10903–10908.
K D. Jones, S G. Stewart, Recent Advances in Steroid Synthesis: A Tribute to Sir Derek Barton, Aust. J. Chem. 2018, 71, 627-633.
N. YT Man, D. R Knight, S. G Stewart, A. J McKinley, T. V Riley, K. A Hammer, Spectrum of antibacterial activity and mode of action of a novel tris-stilbene bacteriostatic compound, Scientific reports, 2018, 8 (1), 6912.
D. J. Power, K. D. Jones, S. S. Kampmann, G. R. Flematti, S. G. Stewart, Nickel catalysed C-N cross coupling of primary imines with subsequent in situ [2+2] cycloaddition or alkylation, Asian J. Org. Chem, 2017, 6, 1794.
T. Miura, T. Nakamuro, S. G. Stewart, Y. Nagata, M. Murakami, Synthesis of Enantiopure C3-Symmetric Triangular Molecules, Angew. Chem. Int. Ed. 2017, 56, 3334 –3338.
M. W. Shi, S. G. Stewart, A. N. Sobolev, B. Dittrich, T. Schirmeister, P. Luger, M. Hesse, Y-S. Chen, P. R. Spackman, M. A. Spackman, S. Grabowsky, Approaching an experimental electron density model of the biologically active trans-epoxysuccinyl amide group—Substituent effects vs. crystal packing, J. Phys. Org. Chem, 2017, DOI: 10.1002/poc.3683.
T. Miura, T. Tanaka, Q. Zhao, S. G. Stewart, M. Murakami, Synthesis of 2-Substituted 2-Amino Ketones by Rhodium-Catalyzed Reaction of N-Sulfonyl-1,2,3-triazoles with 2-Alkenols, Helvetica Chimica Acta, 2017, 100, e1600320.
Z. Yin, D. J. Power, Z. Wang, S. G. Stewart, X-F. Wu. Synthesis of 1, 3, 4-Oxadiazoles via Annulation of Hydrazides and Benzene-1, 3, 5-triyl Triformate under Metal-Free Conditions, Synthesis, 2018, 50, A-E, DOI: 10.1055/s-0037-1609481.
53. K. Woo, S. G. Stewart, G. S Kong, M. L Finch-Edmondson, B. J. Dwyer, S. Y. Yeung, L. J. Abraham, S. S. Kampmann, L. A. Diepeveen, A. M. Passman, C. L. Elsegood, J. E. E. Tirnitz-Parker, B. A. Callus, J. K. Olynyk, G. C. T. Yeoh, George C. T. Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib, Eur. J. Med. Chem, 2016, 120, 275.
52. J. A. Duczynski, R. Fuller, S. G. Stewart, tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions. Aust. J. Chem. 2016, 69, 1172–1179.
51. S. S. Kampmann, N. Y. T. Man, A. J. McKinley, G. A. Koutsantonis, S. G. Stewart, Exploring the Catalytic Reactivity of Nickel Phosphine–Phosphite Complexes. Aust. J Chem. 2015, 1842-1853.
50. S. S. Kampmann, B. W. Skelton, D. A. Wild, G. A. Koutsantonis, S. G. Stewart, An Air-Stable Nickel(0) Phosphite Precatalyst for Primary Alkylamine C–N Cross-Coupling Reactions. Eur. J. Org. Chem. 2015, 5995–6004.
49. S. S. Kampmann, B. W. Skelton, G. C. Yeoh, L. J Abraham, N. A. Lengkeek, K. A Stubbs, C. H Heath, S. G. Stewart, The synthesis and fluorescence profile of novel thalidomide analogues, Tetrahedron, 2015, 71 (42), 8140-8149.
48. J. Chen, K. Natte, N. Y.T. Man, S. G. Stewart, X-F Wu, Convenient copper-mediated Chan–Lam coupling of 2-aminopyridine: facile synthesis of N-arylpyridin-2-amines, Tetrahedron Lett. 2015, 2015, 56, 4843–4847.
47. N. Y. T Man, W. Li, S. G. Stewart, X-F. Wu, Transition Metal-free Methylation of Amines with Formaldehyde as the Reductant and Methyl Source, CHIMIA International Journal of Chemistry, 2015, 69 (6), 345-347.
46. K. D. Jones, J. E. Rixson, B. W. Skelton, K. M. Gericke, S. G. Stewart, The total synthesis of Heraclemycin B through a b -keto sulfoxide and aldehyde annulation, Asian J. Org. Chem, 2015, 2015, 4, 936-942.
45. J. E. Rixson, J. R Abraham, Y. Egoshi, B. W. Skelton, K. Young, J Gilbert, J. A Sakoff, K. M. Gericke, A. McCluskey, S G. Stewart, The Synthesis and Biological Activity of Novel Anthracenone-pyranones and Anthracenone-furans, Bioorg. Med. Chem. 2015, 23, 3552-3565.
44. C. Shen, N. Y. T. Man, S. Stewart, X-F Wu, Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones, Org. Biomol. Chem, 2015, 13, 4422-4425.
43. S. S. Kampmann; B. W. Skelton; D. A. Wild; George A. Koutsantonis; S. G. Stewart, Tris(tri-o-tolyl phosphite-κP)nickel: a coordinatively unsaturated nickel(0) complex, Acta Cryst. 2015, C71, 188–190.
42. M. W. Shi, A. N. Sobolev, T. Schirmeister, B. Engels, T. C. Schmidt, P. Luger, S. Mebs, B. Dittrich, Y-S. Chen, J. M. Bak, D. Jayatilaka, C. S. Bond, M. J. Turner, S. G. Stewart, M. A. Spackman, S. Grabowsky, New J. Chem., 2015, 39, 1628-1633.
41. S. S. Kampmann; A. N. Sobolev; G. A. Koutsantonis; S. G. Stewart; Stable Nickel(0) Phosphites as Catalysts for C-N cross Coupling Reactions, Adv. Synth. Catal., 2014, 2014, 356, 1967–1973.
40. S. G. Stewart, Modern Domino Reactions Containing a Michael Addition Reaction (Chapter 7) Domino Reactions, Concepts for Efficient Organic Synthesis, Tietze, Lutz F. (Editor) 2014, Wiley-VCH.
39. R. A. Boulos, N. Y. T. Man, N. A. Lengkeek, K. A. Hammer, N. F. Foster, N. A. Stemberger, B. W. Skelton, P. Y Wong, B. Martinac, T. V. Riley, A. J McKinley, S. G Stewart, Inspiration from old dyes: New tris-stilbene compounds as potent Gram-positive anti-bacterial agents, Chem, Eur, J, 2013, 19 (52), 17980-17988.
38. J. E. Rixson, B. W. Skelton, G. A. Koutsantonis, K. M. Gericke, and S. G. Stewart, Domino Reactions for the Synthesis of Anthrapyran-2-ones and the Total Synthesis of the Natural Product (±)-BE-26554A, Org Lett, 2013, 4834–4837.
37. T. Miura, T. Tanaka , K. Hiraga , S. G. Stewart, M. Murakami Stereoselective Synthesis of 2,3-Dihydropyrroles from Terminal Alkynes, Azides, and α,β-Unsaturated Aldehydes via N-Sulfonyl-1,2,3-triazoles, J. Am. Chem. Soc, 2013, 135 (37), 13652–13655.
36. E. Eroglu, X. Chen, M. Bradshaw, V. Agarwal, J. Zou, S. G. Stewart, X. Duan, R. N. Lamb, S. M. Smith, C. L. Raston, K. S. Iyer, Biogenic production of palladium nanocrystals using microalgae and their immobilization on chitosan nanofibers for catalytic applications, RSC Adv, 2013, 3, 1009-1012.
35. D. L. Priebbenow, S. G. Stewart, F. M. Pfeffer, Asymmetric Induction in Domino Heck-aza-Michael Reactions, Tetrahedron Lett. 2012, 53, 1468-1471.
34. J. E. Rixson, T. Chaloner, C. H. Heath, L. F. Tietze, S. G. Stewart, The Development of Domino Reactions Incorporating the Heck Reaction: The Formation of N-Heterocycles, Eur. J. Org. Chem, 2012, 544-558.
33. S. G. Stewart, Intramolecular Heck Reactions-Heterocycle Synthesis, Cross Coupling and Heck-Type Reactions 3 Metal-Catalyzed Heck-Type Reactions and C—C Cross Coupling via C—H Activation Science of Synthesis 2012 Tieme.
32. Lutz F. Tietze, S. G. Stewart, and M. Alexander Düfert, Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products (Ch 9), Modern Tools for the Synthesis of Complex Bioactive Molecules, Janine Cossy (Editor), Stellios Arseniyadis (Editor) 2012, Wiley-VCH.
31. M. Bradshaw, J. Zou, L. Byrne, K. S. Iyer, S. G. Stewart and Colin L. Raston, Pd(II) conjugated chitosan nanofibre mats for application in Heck cross-coupling reactions. Chem. Commun., 2011, 47, 12292-12294.
30. Y. S. Yee, S. Kampmann, K. A. Stubbs, B. W. Skelton, B. J. Kaskow, L. J. Abraham, S. G. Stewart, Novel Thalidomide Analogues with Potent NFkB and TNF expression Inhibition, Med. Chem. Commun., 2011, 2, 1073-1078.
29. R. E. Martin, M. E. Polomska, L. T. Byrne, S. G. Stewart An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines, Tetrahedron Lett, 2011, 52, 4878-4881.
28. D. L. Priebbenow, F. M. Pfeffer, S. G. Stewart, A One-Pot, Three-Component Approach to Functionalised Tetrahydroisoquinolines Using Domino Heck–aza-Michael Reactions, Eur. J. Org. Chem, 2011, 1632-1635.
27. J. Zou, K. S. Iyer, S. G. Stewart, C. L. Raston, A Scalable synthesis of catalysts for the Mizoroki–Heck cross coupling reaction: palladium nanoparticles assembled in a polymeric nanosphere. New J. Chem., 2011, 35, 854-860.
26. N. A. Lengkeek, R. A. Boulos, A. J. McKinley, T. V. Riley, B. Martinac, S. G. Stewart, The Synthesis of Fluorescent DNA The Synthesis of Fluorescent DNA Intercalator Precursors through Efficient Multiple Heck Reactions Aust J Chem, 2011, 64, 316-323.
24. J. Zou, S. G. Stewart, C. L. Raston; K. S. Iyer, Surface oxygen triggered size change of palladium nano-crystals impedes catalytic efficacy, Chem. Commun., 2011, 47, 1803-1805.
25. D. L Priebbenow, S. G Stewart, F. M. Pfeffer, A General Approach to N-Heterocyclic Scaffolds Using Domino Heck-aza-Michael Reactions, Org. Biomol. Chem., 2011, 1508-1515.
23. J. Bajsa, A. McCluskey, C. P Gordon, S. G Stewart, T. A. Hill, R. Sahu, S. O. Duke, B. L. Tekwani, The antiplasmodial activity of norcantharidin analogues that may act by protein phosphatase inhibition. Bioorg Med Chem Letts, 2010, 20, 6688-6695.
22. S. G. Stewart, C. J. Braun, M. E. Polomska, M. Karimi, L. J. Abraham, K. A. Stubbs, Efforts Toward Elucidating Thalidomides Molecular Target: An Expedient Synthesis of the First Thalidomide Biotin Analogue, Org. Biomol. Chem, 2010, 8, 4059 - 4062.
21. S. G. Stewart, E. L. Ghisalberti, B. W. Skelton, C. H. Heath, Formation and reactions of azepino[4,5-b]indoles: An unprecedented ozone reaction in the formation of novel benzo[c]naphthyridinones, Org. Biomol. Chem, 2010, 8, 3563.
20. H-d Xie, L. A. Ho, M. S. Truelove, B. Corry, S. G. Stewart, Fluorescent Triphenyl Substituted Maleimide Derivatives: Synthesis, Spectroscopy and Quantum Chemical Calculations, J Fluoresc, 2010, 20, 1077–1085.
19. D. L. Priebbenow, L. C. Henderson, F. M. Pfeffer, S. G. Stewart, Domino Heck-aza-Michael reactions; efficient access to 1-substituted tetrahydro-β-carbolines, J. Org. Chem. 2010, 1787-1790.
18. S. G. Stewart, C. J. Braun, S-L. Ng, M. E. Polomska, M. Karimi, L. J. Abraham, New thalidomide analogues derived through Sonogashira or Suzuki reactions and their TNF expression inhibition profiles, Bioorg. Med. Chem. 2010, 18, 650-662.
17. S. G. Stewart, L. A. Ho, M. E. Polomska, A. T. Percival, G. C. T. Yeoh, The rapid evaluation of Antrodia camphorata natural products and derivatives in tumorigenic liver progenitor cells using a novel cell proliferation assay. ChemMedChem, 2009, 4, 1657.
16. S. G. Stewart, C. H. Heath, E. L. Ghisalberti, Domino or Single-Step Tsuji–Trost/Heck Reactions and their Application in the Synthesis of 3-Benzazepines and Azepino[4,5-b]indole Ring Systems, Eur. J. Org. Chem, 2009, 1934.
15. T. A. Hill, S. G. Stewart, C. P. Gordon, S. P. Ackland, J. Gilbert, B. Sauer, J. A Sakoff, A. McCluskey, Norcantharidin Analogues: Synthesis, Anticancer Activity and Protein Phosphatase 1 and 2A Inhibition. ChemMedChem, 2008, 3, 1878.
14. W. M. Loke, J. M. Proudfoot, S. Stewart, A. J. McKinley, P. W. Needs, P. A. Kroon, J. M. Hodgson and K. D. Croft, Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity, Biochemical Pharmacology, 2008, 75, 1045.
13. S. G. Stewart, T. A. Hill, J. Gilbert, S. P. Ackland, J. A. Sakoff, A. McCluskey, Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity. Bioorg. Med. Chem. 2007, 15, 7301.
12. S. G. Stewart, D. Spagnolo, M. E. Polomska, M. Sin, M. Karimi, L. J. Abraham, Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross coupling. Bioorg. Med. Chem Letts. 2007, 17, 5819.
11. T. A. Hill, S. G. Stewart, S. P. Ackland, J. Gilbert, B. Sauer, J. A. Sakoff, A. McCluskey, Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. Bioorg. Med. Chem. 2007, 15, 6126.
10. T. A. Hill, S. G. Stewart, B. Sauer, J. Gilbert, S. P. Ackland, J. A. Sakoff, A. McCluskey, Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition and anticancer activity, Bioorg. Med. Chem. Letts, 2007, 17, 3392.
9. S. G. Stewart, M. E. Polomska, R. W. Lim,. A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata, Tetrahedron Lett. 2007, 48, 2241.
8. A. McCluskey, S. K. Leitch, J. Garner, C. E. Caden, T. A. Hill, L. R. Odell, S. G. Stewart, BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols, Tetrahedron Lett. 2005, 46, 8229.
7. L. F. Tietze, S. G. Stewart, M. E. Polomska, Intramolecular Heck Reactions for the Synthesis of the Novel Antibiotic Mensacarcin, Eur. J. Org. Chem. 2005, 1752.
6. L. F. Tietze, S. G. Stewart, M. E. Polomska, A. Modi, A. Zeeck, Towards the Synthesis of the New Anticancer Agent Mensacarcin, Chemistry, Eur. J. 2004, 10, 5233.
5. M. G. Banwell, A. J. Edwards, M. D. McLeod, S. G. Stewart, A Chemoenzymatic Synthesis of the cis-Decalin Core Associated with the Novel Anti-Mitotic Agent Phomopsidin, Aust. J. Chem, 2004, 57,641.
4. M. G. Banwell, A. J. Edwards, G. J. Harfoot, K. A. Jolliffe, M. D. McLeod, K. J. McRae,
S. G. Stewart, M. Vögtle, Chemoenzymatic Methods for the Enantioselective Preparation of Sesquiterpenoid Natural Products from Aromatic Precursors, Pure Appl. Chem, 2003, 75, 223.
3. M. G. Banwell, S. G. Stewart, Methyl 6-methoxy-1-oxoindan-4-carboxylate, Org. Prep. Proced. Int, 2001, 33, 177.
2. D. M. J. Wright, S. P. Baker, S. G. Stewart, P. J. Scammells, N6-(5,6-epoxynorbornyl)adenosine Analogues as A1 Adenosine Agonists, Bioorg. Med. Chem. Lett. 1998, 8, 3647.
1. M. G. Banwell, B. L. Flynn, S. G. Stewart, Selective Cleavage of Isopropyl Aryl Ethers by Aluminium Trichloride, J. Org. Chem. 1998, 63, 9139.
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